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Oscars of Hair Return to Vegas

The Professional Beauty Association (PBA) has announced that tickets are now on sale for the 2021 North American Hairstyling Awards (NAHA) 2021. It will take place on August 29th in Las Vegas at the Mandalay Bay Resort and Convention Center. NAHA honors top artists who push the boundaries of skill and creativity. NAHA is a must-attend event for the who’s who of the beauty industry. NAHA 2021 was pushed back to August to ensure it could remain live and in-person. Due to capacity restrictions, a limited number of tickets are available and must be bought in pairs of 2 or 4. For more information visit probeauty.org/naha.

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Tips For Your Next Mass Mailing

Chances are your business is just emerging from Covid and you’re looking to put some momentum into your marketing efforts.  Mass mailing is still one of the most effective promotional tools, but the rules are constantly changing.  When providing databases to be used for mailing or other marketing campaigns, it is important to follow these guidelines for formatting your address files. Unlike first class mail, undeliverable mail will not be returned to you, it will simple be discarded and you will never know.

HERE’S WHAT YOUR MAILING HOUSE WOULD LIKE TO RECEIVE:

  • File should be an Excel spreadsheet (.xls or .csv)
  • File should have column headers (First Name, Last Name, Address, etc.). Headers should be clear and self-explanatory.
  • A separate column should be assigned for each variable field (such as name, title, business name, address). The only 2 exceptions where information can be combined are: 1) City State Zip, and 2) Full Name (ex. Mr. John James).
  • The address line should be in its own column, clear of any other information, in order to pass the USPS address verification. For example, “1234 Fair Oaks Avenue Ste A” should be in a field by itself. Any other information such as department name, floor level, plaza name, care of name, etc. should be in a secondary address column.
  • Addresses should be limited to 2 fields. The USPS address verification can only verify 2 address fields.
  • File cannot have hard returns within a field.
  • Data should be formatted as the customer wants it to appear on printed piece.
  • For projects that use more than variable text (such as photos or signatures), it is highly recommended to consult your shipper.

 

EXAMPLE OF AN ACCEPTABLE DATABASE

 

EXAMPLE OF AN UNUSABLE DATABASE

 

WHAT ABOUT SINGLE LETTERS?

If you are sending individual letters out to clients, be sure to address the envelope correctly. Here is some advice from USPS:

  • Always put the address and the postage on the same side of your mailpiece.
  • On a letter, the address should be parallel to the longest side.
  • All capital letters.
  • No punctuation.
  • At least 10-point type.
  • One space between city and state.
  • Two spaces between state and ZIP Code.
  • Simple type fonts.
  • Left justified.
  • Black ink on white or light paper.
  • No reverse type (white printing on a black background).
  • If your address appears inside a window, make sure there is at least 1/8-inch clearance around the address. Sometimes parts of the address slip out of view behind the window and mail processing machines can’t read the address.
  • If you are using address labels, make sure you don’t cut off any important information. Also make sure your labels are on straight. Mail processing machines have trouble reading crooked or slanted information.

Automated mail processing machines read addresses on mailpieces from the bottom up and will first look for a city, state, and ZIP Code. Then the machines look for a delivery address.

If the machines can’t find either line, then your mailpiece could be delayed or misrouted. Any information below the delivery address line (a logo, a slogan, or an attention line) could confuse the machines and misdirect your mail.

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The Power of Stem Cell Extract

Keracell is a company based in California that offers hair and skin care products based on multiple human cell stem cell technology. Their ‘Hair Rewind Package’ targets hair loss and scalp and follicle regeneration, while its ‘Hair Reset Package’ claims to strengthen fine and thinning hair and seal the hair cuticle for added shine and durability.

?Keracell products are based on multiple human cell stem cell (MHCsc)™ technology derived from the combination of Fibroblasts and Mesenchymal Cells utilizing Exosome delivery. This technology is then combined with other proven cosmetic “bio-active” ingredients such as vitamins, minerals, targeted peptides and technologically advanced ingredients for results driven solutions for the face, hair and body. 

To learn more about these advanced products, Hair Authority met with Keracell CEO, Ekin Ozlen

 What does “Keracell” mean?

‘Kera’ stands for keratinocyte and ‘cell’ refers to the human stem cell extract that we infuse within our hair and skin product lines.

 

What is the difference between human stem cell extract and plant or organic stem cells?

The way I explain it is that ‘like wants like’. We are human, so our cells will be best activated and revitalized by other human stem cells. In this case it’s a human stem cell extract that is topically applied. I’m not going to downplay the power of plant-based stem cells because we have a Botanica line, but they’re never going to give you the result that human stem cell extract can provide. Botanica uses bamboo stem cells, cotton stem cells and stem cells from the argan tree in a special botanical line and they provide a benefit at a more competitive price. But to my mind, we are human, and our scalp and hair is going to react best to a human stem cell extract.

 

You put a lot of emphasis on the fact that your formulations contain multiple human cell stem cell technology. Why is that?

We’re innovators in human stem cell extract-based products. We believe the efficacy of our product line is due to the fact that we’re pulling from multiple human source materials. SkinMedica is a well-respected competitor that also utilizes human stem cell extract, but they’re pulling from only one source.

There are so many different variables and each one offers different benefits. For example, plastic surgeons love products based on adipose tissue, because for them it’s all about boosting collagen. Our products are highly effective because of our starting materials. I believe the multiple human cell stem cell extract that we’re putting in our products can improve anyone’s skin or hair.

 

Is there any risk of rejection?

We have seen extremely low allergy rates, which is what I love about human stem cell extract topically applied. It basically brings the skin back to homeostasis. Everyone can benefit, whether they have oily skin or dry skin.

 

How does your product penetrate the skin barrier?

It’s due to the tiny nanoparticles. Product penetration is the most important thing when it comes to performing better and that’s definitely a defining factor in our product line. When you use a product, you can feel if it’s well manufactured. It won’t lay on the surface of your skin; it’s going to penetrate without leaving a residue. You shouldn’t need a roller or anything to prick the skin. Keracell will absorb into the skin because of those minute nanoparticles.

 

Did you have to educate people and help them understand the technology that has gone into your products?

It was extremely challenging because we were the first human stem cell extract brand to go into major retail. It has been difficult to educate not only consumers, but also the beauty advisors that are selling the product. My goal now is to get the word out about the power of human stem cell extract topically applied. People hear all the time about human stem cells for wounds and shoulder or knee injuries, so just imagine using that rejuvenating power on the skin and scalp. It’s incredible. There’s nothing out there that can give you the same results.

 

Did some people who embrace the technology believe that science is the future of beauty while others were cautious because stem cells evoked negative associations?

That’s very important and why I rely so much upon the education component of these products and the fact that they’re clinically validated. I don’t know why people immediately think stem cells all come from an aborted baby. Even some people who work in doctors’ offices say, “but where does it come from?” I don’t know why everyone always goes there, but it’s the first question I get. But l actually welcome that question because I love educating and telling people that it’s going to be the greatest thing they’ve ever used.

 

Tell us about the clinical studies and the efficacy of the product.

The complete extract has been tested as well as the peptides within our product. They were evaluated by researchers at Stanford University. It’s all on the website. If you click on Keracell MD, it goes on a deep dive into all of that. This is important when it comes to a hair loss product because you want to know if it’s really going to work. Does it have clinical validation? The research gives you peace of mind.

 

Would you regard your hair products as a cosmetic, a wellness product or a drug?

Definitely a wellness product and a cosmetic. Everything that you see on our packaging I’ve written myself and I’m extremely careful about what I tell clients. I want to be mindful of the regulations, but I also want to tell them the things I’ve seen and that clients have experienced. I am careful not to make medical claims.

 

Were you ever tempted to include minoxidil in your formulation?

No, because minoxidil is a drug and as soon as you stop using it, your hair falls out. That’s the antithesis of what we stand for. I don’t ever want people to feel trapped in any hair regimen. That’s super important to me. It’s not fair to the consumer to get them into a product where if they stop, boom, their hair falls out. That’s terrible. We want to help their body to do its job better. And that’s what our products really do. They strengthen the user’s natural ability.

 

What was the first haircare product you introduced?

The first product is still our hero product. It’s called the “Hair and Scalp Revitalizing Spray”. We probably have 40 products now, but I still consider this our hero product.

 

 

We’re surprised you chose a spray, not a dropper to avoid wastage.

Actually, the spray is very user-friendly. Whether your hair is wet or dry, you just move the spray around a little and spread it with your fingertips. It dries without leaving any residue. There’s no scent. You can use it for color treated hair, if you’re doing Brazilian blow dry, or if you are suffering from traction alopecia because you have extensions. Obviously if you have a shiny bald head, it’s not going to work. You have to have hair follicles that are still alive.

 

“Hair and Scalp Revitalizing Spray” was the first foot in the door. What product followed?

We wanted to build a system around that product. We didn’t want people buying things that were going to interfere with the efficacy of the hair growth spray so next we introduced a shampoo and a conditioner. It has tea tree, kale, quinoa, lemon, and rosemary. When you use them, your hair is shiny and voluminous almost immediately. The tea tree will address any kind of dryness or flakiness; I happen to have a dry scalp and I was on dandruff shampoo my entire life and it’s really helped me with the dryness.

People need to understand that you have to balance whether your hair tends to be oily or dry. It has to have the right balance before hair is going to grow properly. A lot of times people don’t realize that there’s inflammation in their scalp because of an imbalance. Our shampoo and conditioner addresses that. That’s why it’s important to use all the products in our five-product system. Each one of the products is responsible for a different result. And those results combined together are going to give you the best hair growth.

 

What is the recommended regimen for somebody who uses all five products?

Wash your hair three to four times a week. Protect the natural oils. A lot of people over wash their hair. They’re fussing with it. Set yourself up for success. Use a wide tooth comb, I recommend brushes that are gentle on the hair. Sleep with a satin pillowcase. Don’t put your hair up in tight ponytails.

I tell my clients to, “walk me through a day in your hair’s life” so we really get to understand what they’re doing that may not be beneficial to their hair or scalp. Then we get into our products. Shampoo, conditioner – obviously a leave-in conditioner to protect the hair shaft. It’s important to protect the hair that we already have, not just worry about growing more hair.

The number one thing my products do is help reduce the shedding process almost immediately. Whether you’re in your hair’s growth phase or not, the moment you start using the products, you’re going to notice your hair looks lustrous and your follicle is anchored. You’re slowing that shedding process and reducing inflammation in the scalp. Then a couple of months go by – you have to give it a couple months because everyone’s in a different growth phase when they start using the product line – and you start noticing that your hair appears thicker. All of a sudden, your hairline is changing.  I can speak from experience. I used to pull and tug at my hair when I used a curler.  Now my hairline is nice and full again.

 

Do you also see benefits on the surrounding skin?

Great question. A lot of times when people spray the product, they let it drip and don’t wipe it off and we’ve seen impressive forehead improvement. Things like improved skin pore size, wrinkles, brown spots, just from the spray hitting the skin. We didn’t expect that.

We had a lady who was about 80 years old who was testing the hair and scalp revitalizing spray. She used it for 90 days and her hair started coming back in its natural color.  She had gone completely gray, but she began seeing all these strands of hair coming back in her original, dark color. That’s just one of many things we’ve seen and that’s why I’m saying there’s nothing on the market like this. We’re combining CBD and human stem cell extract in four products. No one’s doing that. That’s an amazing combination – two superpowers for the skin.

 

You also have an MD collection. Why did you create one product for the general public and another for professionals?

We wanted to create a line for medical practitioners to send their clients home with. They are doing a lot of ablative treatment, so they need products that are fragrance free. Our over-the-counter line has essential oils, which isn’t ideal for professionals if they’re doing PRP for the scalp or any kind of dermaplaning or micro needling.  So, we said, let’s design something specifically for those patients that will be great during treatment and that they can also use daily afterwards. It had to be completely fragrance free and be extremely efficacious to lessen downtime and speed up healing. Healing time is very much a factor when everyone has a fast-paced life. We’re all too busy to take two weeks out before we can go back out in public again.

 

What makes the combination of stem cell extract and CBD in some of your products so effective?

CBD is not just for anti-inflammation. It’s incredible for eczema, psoriasis, anti-acne stress and reducing anxiety. We’ve even used it to create a beauty mask that enhances your skin while you sleep. What could be better than having your skin repaired naturally while you rest?

 

Do you have any competition as you pioneer these technologies?

Many people always ask me that and I look around and no one is doing what we do. We’re definitely innovators in this space. They’re not doing it with such a high science brand. We’re bringing advanced technology down to a consumer level.  People want to understand what they’re putting on their skin. Consumers are super intelligent now. They’re all over the internet and I love giving them the knowledge to understand and make the right choices. It’s such a confusing market with so many options out there. You really need to know what you’re getting into when you’re applying a product every day.

 

In many ways Asia has become a leader in the development of new beauty technologies. Is Keracell leading the way in stem cell extract research?

It’s give and take. I live in California and there’s a lot of interesting stuff going on in the beauty world here. I was at my plastic surgeon’s office the other day and having some laser treatment and I started talking to the nurse. They know that I own a brand that’s human stem cell extract based, and she started telling me how they have started doing IVs of human stem cell off-label for children with autism. I was amazed that a plastic surgeon’s office is doing this. Everywhere in the world there’s something that another country doesn’t know about. I love that we’re learning from each other and building upon that to make products that are even more efficacious.

 

Looking over the horizon, what can we expect to see next?

Our Botanica line is exciting for us because you cannot import human stem cell extract-based products into the EU right now. So, we said, let’s take something that’s botanical and make it a powerhouse alternative. We went to work on that and then the pandemic hit, so we immediately switched gears and developed a botanical hand sanitizer because that’s what everybody needed at the time.

When you’re on the cusp of new technologies, it’s tempting to premium price and recover your investment, but you decided to make your products affordable to a broad market.

I love helping people to feel beautiful. I’m inspired by that. I want to help people deal with the super emotional aspect of hair loss. I like watching their faces light up when their hair’s growing and they don’t have to wear hats anymore.  I’ve had so many instances where clients would call me crying about hair loss. It’s really emotional. Keeping our prices where more people can afford it allows them to actually do something.  In all honesty, our products really should be much more expensive because there’s so much in them, but I want them to remain accessible.

 

What is the key thing you would like readers to know about Keracell?

If they’ve never used a human stem cell extract-based product, the time is now.  They will never look back. That’s what I want people to know. They’ve got to start using products that are efficacious and stop wasting money on things that don’t deliver. We’re extremely results driven.

 

If they started using the product tomorrow, how long before they see a benefit?

It depends on the product. I have some skin care clients who told me their skin was better within a few days. Speaking from my own experience, I noticed right away that my pores were getting smaller, and I started seeing fine lines diminishing and brown spots on my skin going away. Of course, I started using the hair products and my hair was growing like a weed. In fact, I was also using our lash and brow serum and I had to start cutting my eyelashes with scissors because they were hitting my sunglasses. This is a very powerful product line.

Much of the stem cell research was carried out by the medical community and it’s only now that people are becoming aware of the power of human stem cell extract.

I’m so grateful that’s happening in the medical industry because it’s giving us credibility as a skincare brand. We were concerned at first because when you’re so far ahead with technology people may not be ready for it. But I better feel now that the medical community is shedding light on this powerful agent. We are very confident about the future.

 

About Ekin Ozlen: Keracell is pretty much me.  I was a model for many years with Ford Models in New York. I live in LA now and I’m partnered with a formulator. We are doing our best to educate people on the power of human stem cell extract.

 

About Keracell: The company offers a skin care line utilizing multiple human cell stem cell technology developed by two Ph.D. biomedical scientists with expertise in stem cell research and cancer molecular biology. Keracell’s MHCsc Core Technology has undergone Liquid Chromatography-Mass Spectrometry (LC-Masspec) at Stanford University Proteomics Core Facility (Stanford, CA) to detect the full array of proteins and peptides (well over 540 balanced specifically for wound care/skin care). Gene Expression Analyzation (built-in auto- growth controlling/regulating mechanism in the cell). ELISA Assay Protein Marker  (96 well plate for stability, quality, quantity, consistency. Clinical Trial Testing (Placebo, Solely using MHCsc media).

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Why Genetically Engineered Foods May Cause Hair Loss

Genetically Engineered Food is food that has been methodically altered or modified by scientists; therefore, this food is no longer natural. GMO foods allow foreign genes, bacterial and viral vectors , viral promoters, and antibiotic marker systems to be engineered into food. A significant percentage of processed foods purchased today contain some genetically engineered (GE) food products. Consumers have no way of knowing what foods are genetically engineered because the U.S. Food and Drug Administration (FDA) does not require labeling these products.

The GMO process combines plants, animals, viruses and bacterium genes – that do not naturally occur together in nature – to better a species.

 

Can GMO Foods Impact the Health of Hair?

What we eat will undoubtedly impact our health and our hair. A study diet of processed foods, fast foods, and lack of nutrients will reflect the hair quality.

Genetically modified seeds were initially introduced to the market to reduce insect damage to crops. The biggest problems with genetically engineered seeds are produced with herbicides and insecticides that are toxic and, Overtime diminishes a person’s health.

Research shows that GMO foods are devoid of the proper nutrients the body needs to promote healthy hair and good health.

Sugar (artificial sweeteners and high fructose are often hidden in many of our favorite foods. Millions of men, women and children have a steady diet of processed foods, fast foods, and cereals, all of which have food additives and preservatives made of chemicals. Many people have a difficult time digesting these foods.

Our bodies require real food, fruits, vegetables and natural nutrients to give the cells what is needed to support healthy hair; otherwise, the hair will show signs of hair thinning or sudden hair loss.

 

Risks Associated with GMOs

The risks and disadvantages associated with GMOs are extensive both for human health and for agriculture.

 

Effects on Overall Health

There are many health conditions that are being reported because of GMOs, including:

When the immune system has been weakening or compromised, the body cannot absorb the nutrient necessary to enter into the cells to feed the organs that keep you alive and well.

 

How to Protect Yourself

Purchase USDA Organic Foods when possible

Clean all fruits and vegetables with vinegar and aluminum-free baking soda

Read labels: If you cannot pronounce the words, chances are the foods are not healthy

Limit the amount sugar intake

As hair business professionals to help our clients when we see hair loss signs, we must understand the relationship between the foods we eat and how it impacts our body and hair.

 

United States

The U.S. Food and Drug Administration currently requires labeling of GE foods if the food has a significantly different nutritional property; if a new food includes an allergen that consumers would not expect to be present or if a food contains a toxicant beyond acceptable limits.

Mandatory labeling of genetically engineered (GE) foods in the United States has been proposed, but not enacted at the national, state and local levels.

 

Resources

 

Joanne Washington is a Hair Restoration Specialist. Hair Loss Expert, Coach and Educator.  For more information email joanne@hairoots.com. 714 674-7668.

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40 Flaxen Facts about Blonde Hair

Hair color is based on how much melanin, or pigmentation, is in the hair. Two types of melanin create hair color: 1) eumelanin and 2) phaeomelanin. The more eumelanin a person has, the darker their hair will be. Phaeomelanin works in a similar way, except instead of causing hair to be blacker, it causes hair to be more red. Low levels of both eumelanin and phaeomelanin characterize blonde hair.

Blonde hair can range from practically white (platinum blonde) to a dark golden blonde. Strawberry blonde, the mixture of blonde and red hair, is the rarest type of blonde hair.[4]

Because blond hair tends to turn darker with age, natural blonds make ups just 2% of the population.

Just 1 in 20 white American adults is naturally blonde, and roughly the same ratio applies to white northern Europeans. Virtually 1 in 3 white adult females dye their hair a shade of blonde.

 

Interesting Blonde Hair Fact:

The gene that causes blonde hair in Melanesians is different than the gene that causes blonde hair in Caucasians (Graham Crumb, Port Vila, Vanuatu).

The Melanesians of New Guinea are the only dark-skinned group of humans known to have a high blonde hair rate.

Recent excavations in China’s Taklamakan desert have found mummies from as far back as 1800 B.C. with strikingly blonde hair.

Jean Harlow was Hollywood’s first blonde goddess. She dyed her hair with a mixture of peroxide, household bleach, soap flakes, and ammonia until it fell out and she was forced to wear a wig.

Princess Diana spent almost 4,000£ ($6,284.80) a year to have her hair bleached.

In Greece, blonde hair was associated with prostitution. Messalina, a Roman empress, would hide her black hair with a blonde wig when she visited the brothel every night.

Greek dramatist Menander (342-291 B.C.) once wrote, “No chaste woman ought to make her hair yellow.”

Nearly 2,000 years before Homer, during the time of the Proto-Indo-Europeans, blonde hair was connected to the worship of the sun and fire and to the adoration of a yellow dawn goddess. The Persians plaited their beards with golden threads, and the Assyrians powdered their hair with extravagant clouds of gold dust.

Marilyn Monroe, who was not a natural blonde, refused to allow other blonde actresses on the film set with her. Her natural hair color was brown.

I like to feel blonde all over.- Marilyn Monroe

German blondes were taken captive during the Roman era and had their hair cut off to be made into wigs for fashionable ladies. Successful wars were a source of a large influx of blonde hair.

Northern Europe has the most blondes. However, even most natural blonde babies lose their blonde hair once puberty sets in. Additionally, women find that after their first pregnancy, their hair and skin darken permanently.

The word “blonde” is derived from several possible sources. Some scholars think it derived from the Medieval Latin blundus meaning “yellow,” the Old Frankish blund, meaning “grey haired” or “to mix,” or from the Old English beblonden meaning “dyed.”

Influenced by Richard Wagner, Elizabeth Nietzsche, the sister of the famous philosopher, selected an entire community of people based on their blonde hair and blue eyes and shipped them off to an isolated village in Paraguay in order to plant the seed of a new race of supermen. The village still exists.

Ancient women often turned to disgusting methods to achieve blonde tresses

In Ancient Rome, women tried to dye their hair blonde with pigeon dung. In Renaissance Venice, they used horse urine.

Hydrogen peroxide was discovered in 1818, but there was little application for it until 1867 when it was found that it could bleach hair. It quickly became popular throughout Europe and America, superseding everything else that had been used as bleach before then.

During the Renaissance, society women spent hours on the balconies of their mansions bathing and rinsing their hair with a tincture known as aqua bionda or aqua di gioventu. They would wear a crownless straw hat with a wide brim called a solana. The hat shaded their faces and skin from the sun, while their hair was combed out over the hat and exposed to the sun. There are records of women developing heatstroke, headaches, nosebleeds, and even blindness.

Blonde hair is seen throughout fairy tales, including Rapunzel, Rumpelstiltskin, Cinderella, and Goldilocks. In fairytales, blonde hair often suggests strength, untarnished beauty, indestructibility, youth, and high value. In contrast, vice is association with hairy, dark, and ugly.

During the Middle Ages, blonde women were held with suspicion, and by the mid-14th century, depictions of Eve were consistently giving her free-flowing locks of golden blonde hair that marked her as an evil temptress. An image in 1356 by Bartolo di Fredi in San Gimignano depicts the creation of Eve as a pale and sensuous blonde emerging from the ribcage of a sleeping Adam.

Eve, the blonde temptress

Meteors were once called “comets” after the Latin word comes, meaning hair, and were named for their flowing golden tail of hair as they flashed through the sky.

Dr. Tony Fallone noted in 1997 that hair color is the root of a person’s personality. Blondes are typically more outgoing and lively and are perceived as more feminine than women with other hair colors. According to Fallone, being blonde is not a hair color, but a state of mind.

1Bartolo di Fredi in San Gimignano depicts the creation of Eve

Alfred Hitchcock, the “master of suspense,” was obsessed with blondes and cast only blondes in his movies. His favorite blondes included Eve Marie Saint (North by Northwest), Joan Fontaine

(Suspicion), Carol Lombard (Mr. and Mrs. Smith), Janet Leigh (Psycho), Grace Kelly (Dial M for Murder, Rear Window, and To Catch a Thief), and Tippi Hedren (The Birds and Marni). Scholars have noted that Hitchcock’s blondes have become one of the most potent icons of our era.

Blonde-haired heads have more strands of hair than red- or dark-haired heads. Blondes have approximately 140,000 hairs compared with 108,000 for their darker counterparts.

Little Known Blonde Hair Fact

Darker hair naturally provides more of a protective barrier, which means brunettes need less hair than blondes to protect their scalp

Barbie, a blonde, is the most popular doll in the world.

The genetic mutation that created blonde hair in Europe happened about 11,000 years ago, approximately during the last ice age.

While blonde hair is a recessive gene, it is not a disappearing gene. The World Health Organization and others erroneously published a report that claimed people with blonde hair would become extinct by 2202.

Scientists believe that blonde hair evolved in sun-deficient climates so that the body could synthesize vitamin D more efficiently.

Other scholars, such as anthropologist Peter Forst, claimed blonde hair evolved very quickly as a means of sexual selection. The blond hair and blue eyes of some northern European women made them more alluring to men.

Most researchers believe that blonde hair evolved more than once in different parts of the world. In fact, blonde hair is not found just in Northern Europe but also in Asia, eastern Afghanistan, northwestern Pakistan, Turkey, southwestern and northern Iran, Israel, western Syria, northern Iraq, Palestinian territories, Jordan, Lebanon, the Berbers in North Africa, and aboriginal Australia.

Interesting Blonde Beard Fact:

Blonde beards grow faster than darker beards.

Blond beards grow faster than dark beards.

The blonde stereotype has been divided into three categories: 1) the ice-cold blonde (Grace Kelley), 2) the blonde bombshell (Brigitte Bardot), and 3) the dumb blonde (Marilyn Monroe).

The term “blonde” came from French and kept its masculine and feminine forms; consequently, as a noun, “blond” is a fair-haired male, while “blonde” is a fair-haired female. However, when the word is used as an adjective, “blond” can be used for both males and females; however, “blonde” can also be used to describe a woman or girl with fair hair.

The “Dumb Blonde” joke may be rooted in the 1775 satirical play “Les curiosites de la Foire,” in which a blonde French courtesan named Rosalie Duthe is portrayed as being less than intelligent. Research indicates that blondes are viewed as less intelligent than women with darker hair. However, modern science shows that there is no evidence of intellectual differences based on hair color.

Dolly Parton’s 1967 song “Dumb Blonde” challenged the dumb blonde stereotype with its lyrics. She claimed that she is not offended by all the dumb blonde jokes because she is not dumb. And she is also not a true blonde.

Blonde women are more susceptible to age-related macular degeneration (AMD), an eye condition that can cause blindness.

Blondes produce less melanin, which leaves their skin more susceptible to skin cancer.

More Interesting Blonde Hair Fact:

Research shows that guys prefer brunettes over blondes as long-term mates

According to several surveys, men do not prefer blondes—at least not as serious mates. Men prefer brunettes as long-term partners because they view them as more reliable and steady.

A Lithuanian firm called Olialia (ooh-la-la) announced in 2010 that it was going to build a resort in the Maldives that would employ only blonde women. It will also have a special airline staffed by blondes only that would take customers to the island. The resort was scheduled to open in 2015.

Margaret Thatcher’s hair became more blond as she became more powerful.

 

This article was first published in 2016 in FactRetreiver and is reprinted with kind permission of the author, Karin Lehnardt. Karin graduated with a BA and MA in English and Rhetoric from Brigham Young University and later worked towards a PhD at Northwestern University in Evanston, Illinois. She has been a university writing tutor and writing instructor for many years and loves researching, reading, writing, and discussing ideas.

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Tips from a Top Dating Site

Zoosk is an online dating site and mobile app with 40 million users in over 80 countries. Subscribers are split evenly between men and women.

Uploading personal information is easy.  Zoosk takes your profile from the social media accounts you’ve already created and integrates it into your new Zoosk account.

There are plenty of other dating apps out there like Hinge, eHarmony, OkCupid, Tinder, Bumble, Plenty of Fish and Match, but Zoosk uses its 40 million users to get interesting feedback on things that get will make you more attractive.

 

Hair is the first thing men notice in a woman:

A 2013 survey revealed that 89 percent of men said that hair is the first thing they notice in a woman!

This was surprising since 71 percent of the women surveyed said that they don’t expect potential suitors to even notice their hair.

What hair style was preferred? According to the Zoosk survey, most men prefer women to wear their hair down.

 

This confirms another study conducted by Little research that explored the effect of women’s hairstyles on people’s behavior.

In their study, male and female pedestrians were observed while walking behind a woman who dropped a glove and apparently was unaware of her loss.

In three separate experiments, the woman wore her long dark hair in different hairstyles: once with her hair falling naturally on her shoulders, then with her hair in a ponytail, and finally with her hair twisted in a bun.

These hairstyles had no effect on other women, but men were more likely to assist a woman with the longer hair that fell naturally on her shoulders and back.

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Dusting Away Dandruff

There’s an unlikely culprit behind the itchy, flaky scalp condition better known as dandruff. It is caused by a yeast species known as Malassezia, the dominant member of an extensive community of fungi in human skin, also known as the mycobiome.

When resident scalp Malassezia feast on sebum, the oily substance produced by hair follicles, they break the sebum down and release free fatty acids. In some individuals, the fatty acids can trigger skin inflammation and hyperproliferation, leading to dandruff.

“Frequently, our normal, commensal fungal flora exist happily on most of us. In some people, however, they induce disorders like dandruff,” explained Thomas Dawson, a hair and scalp expert and Senior Principal Investigator at the Skin Research Institute of Singapore (SRIS), a tripartite collaboration involving A*STAR, NTU, and Singapore’s National Healthcare Group.

Thankfully, over-the-counter medicated shampoos have been soothing the itch of dandruff for decades. These formulations contain a range of active ingredients, most commonly zinc pyrithione. Exactly how these chemicals impact the mycobiome to alleviate dandruff has, until now, left scientists scratching their heads.

In collaboration with members of the international Malassezia Research Consortium, Dawson’s team tested shampoos containing various antifungal agents on the scalp mycobiomes of 35 study participants. They used the gold standard assay—the antifungal susceptibility test, or AFST—alongside fungal culture and genomic techniques to track changes in the growth dynamics of Malassezia for two weeks post-treatment.

Studying the scalp mycobiome proved to be a slippery task with the researchers facing several experimental hurdles. For one, oil and water don’t mix. Most antimicrobial assays such as the AFST are water-based, but Malassezia aren’t. “The big issue with antifungal susceptibility testing is that Malassezia are lipid-lovers. They live in sebum, a strongly hydrophobic environment, and most testing is done in water,” said Dawson, who was the corresponding author on the study.

There were also other logistical problems that made compliance difficult. For example, getting the participants to comply with the study’s strict shampooing regimens was a challenge, as some of them had to avoid washing their hair for up to two days.

Ultimately, zinc pyrithione was found to be superior to other antifungals for keeping dandruff-causing Malassezia at bay. “The optimal antifungal performance of zinc pyrithione shampoos is when they are used every other day,” recommends Dawson.

Follow-up studies will take a deep dive into how the mycobiome influences skin biology. “This should help us learn what Malassezia are doing on the skin and how to potentially intervene with non-antifungal technologies,” he said.

This article was made for A*STAR Research by Wildtype Media Group. The A*STAR-affiliated researchers contributing to this research are from the Skin Research Institute of Singapore (SRIS).

References: Leong, C., Wang, J., Toi, M.J., Lam, Y.I., Goh, J.P.Z., et al. Effect of zinc pyrithione shampoo treatment on skin commensal Malassezia. Medical Mycology 0, 1-4 (2020) | article

 

About the Researcher – Thomas Dawson, Senior Principal Investigator Skin Research Institute of Singapore:

Thomas Dawson earned his PhD in pharmacology from the University of North Carolina in 1994. He then joined the Duke University Medical Center from 1994-1996 as a Pediatric Clinical Medical Genetics Fellow. From 1998-2015 he worked in Procter & Gamble’s Beauty Technology Division, before joining A*STAR’s Institute of Medical Biology (IMB) to develop and lead translational programs in hair and scalp biology. In 2018, Dawson moved to the Skin Research Institute of Singapore (SRIS), where he is currently a Senior Principal Investigator. Dawson has over 30 years of research experience in end-to-end drug discovery, 30 granted patents, multiple products in the market, and a unique background in skin, hair and microbiome research.

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Costco Talks Hair Loss

Costco devoted a full page to hair loss solutions in the February issue of its monthly magazine, Costco Connections.  The special feature article focused on stress as a major contributor factor before listing other behavioral and lifestyle factors.

Author, plastic surgeon, Dr Patrick Angelos talked about the usual washing, brushing and drying caveats but provided no new insights.

However, the article did serve as an excellent stage for Costco to promote its own Kirkland Signature Minoxidil Foam and Lotion, which it sells at a deeply discounted price.

Costco has also featured Theradome, Capillus and HairMax hair growth lasers in the past, but has not sold a Kirkland Device.

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Research: Examining hair loss and the outlook for 2021

 

Samumed – The San Diego-based biotech of Turkish origin, Samumed, currently owns the most advanced drug for hair loss problems. Samumed’s wnt activator SM04554 is undergoing a phase 3 clinical trial in Turkey with an estimated completion date of January 2021, according to the clinicaltrials.gov page. While the drug is not intended to be a powerhouse, it may be a valuable add-on treatment or alternative to currently approved drugs if approved.

 

SM04554. Breezula – This androgen receptor antagonist from Cassiopea is currently the second most advanced drug in the hair growth industry. A phase 3 study was expected in 2020, but due to the unexpected events of 2020, the study was postponed and is expected to start in the first half of 2021. Cassiopea also has an ongoing Phase 2 study for female patients using Breezula that is expected to report data in the second quarter of 2021.

 

Follicum – Another late-stage topical drug, FOL-005 from Follicum, will report key phase 2 trial results in the spring of 2021. This study is especially important for Follicum as it is the first time that the peptide FOL-005 has been topically tested on androgenic alopecia patients (hereditary hair loss). before a larger industry partner comes along to bring the drug to market for approval in a pivotal phase 3 trial.

 

Shiseido – Shiseido’s surprising follow-up trial of RCH-01 is expected to end in the fourth quarter of 2021, but there is no guarantee we will see the data next year. This time, the trial involves multiple injections of dermal sheath cup cells over 12 months. Hopefully, meaningful results will be seen this time.

 

HairClone – While HairClone will not technically offer a treatment itself in 2021, it is largely certain that the company will be ready to supply cultured / expanded dermal papilla cells to doctors in the UK who can use the cells to treat patients in 2021. A few timely government grants in 2020 were able to keep HairClone afloat and move towards their goal of human application in 2021.

 

Kintor – As of December 29, 2020, Kintor has completed enrollment in a Phase 2 clinical trial testing 120 male patients in China. The trial involves multiple dose cohorts and is conducted over a 6-month period. According to Kintor’s latest press release, “The Group expects to complete the clinical study report (CSR) and release the data for the phase II clinical trial in 2021 and a phase III clinical trial (for pyrilutamide) in the second half of 2021 to start.” Kintor sounds great at the moment, let’s hope they live up to their forecasts.

 

Stemson – While a clinical trial for Stemson is possible in 2021, it’s more likely we’ll get a timeline for a clinical trial with Stemson sometime in 2021. Stemson is the only current active hair augmentation company in the US and has recently made a $ 7.5 million investment from Allergan and a UK firm to get their program started.

 

Triple Hair TH16 – The all-natural OTC (over-the-counter) in the Triple Hair pipeline. TH16, is expected to be released in the first quarter of 2021, according to the company’s website. According to the company, TH16 outperformed 5% minoxidil in human patients in a self-sponsored clinical trial. While specific details have not been disclosed, some decent looking photos were shared in an exclusive article in ‘Follicle Thought’. The main ingredients of TH16 are said to be reservol and melatonin, two compounds that have been shown to support hair growth in laboratory studies. The formula is marketed for both men and women. Stay tuned for further updates direct from Triple Hair Management in Q1 2021.

 

University of Wisconsin Hair Cap – Hair Cap – In September 2019, news came out from the University of Wisconsin that a unique new wearable device could become a new useful treatment for hair growth. No news up to now.

 

Hans J. Diks, European editor International Hair Authority, Independent expert on hair problems.

More information: https://www.haarproblemen.nl/

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Hair Regrowth with Cannabidiol (CBD) – Rich Hemp Extract A Case Series

Cannabis Research Society of Marijuana “Cannabis” is an open access peer-reviewed journal dedicated to the scientific study of marijuana/cannabis from a multidisciplinary perspective. Consistent with the mission of the Research Society on Marijuana (RSMj), the journal publishes empirical research of the determinants, correlates, consequences, contexts, and assessment of marijuana use.

ABSTRACT

Androgenetic alopecia (AGA) is the most common cause of hair loss. Several FDA approved medications are available but offer limited results. Studies have shown that the endocannabinoid system (ECS) is a key player in hair follicle cell growth. The ECS cannabinoid type one (CB1) receptors are well expressed in the hair follicle cells. Cannabidiol CBD is a negative allosteric modulator of the CB1 receptor and has been shown to result in hair shaft elongation. In addition, the hair follicle cycle phases are controlled by the ECS vanilloid receptor-1 (TRPV1). CBD has also been shown to increase Wnt signaling pathways that are involved in the differentiation of dermal progenitor cells into new hair follicles and maintaining the anagen phase of the hair cycle. The effects of CBD on hair growth are dose dependent and higher doses may result in premature entry into the catagen phase via a receptor known as vanilloid receptor-4 (TRPV4). Topical application of CBD reaches hair follicles where it is a CB1 negative modulator, and TRPV1, and TRPV4 agonist.

A study was done of 35 subjects with AGA using a once daily topical hemp oil formulation, averaging about 3-4 mg per day of CBD and minimal amounts of other cannabinoids for six months. A hair count of the greatest area of alopecia was carried out before treatment and again after six months. The results revealed that men did slightly better than women, and the vertex area did better than the temporal areas. On average, there was statistically significant 93.5% increase in hair after 6 months. All subjects had some regrowth.

There were no reported adverse effects. Since the CBD works through novel mechanisms different from finasteride and minoxidil, it can be used in conjunction with these current drugs and would be expected to have synergistic effects.

Androgenetic Alopecia (AGA) is a very common condition, that occurs in both men and women, and increases in prevalence with age. It is by far the most common cause of baldness and hair thinning. It generally starts in the third and fourth decades of life and significantly increases in prevalence in women after menopause. It is estimated that 50% of Caucasian men and 19% of Caucasian women are affected by age 50 (Shankar et al., 2009). There is a lower prevalence and severity of the condition in Asian and black men. AGA may adversely impact a person both psychologically and socially, especially in women (Levy & Emer, 2013). The condition is characterized by follicular miniaturization in a specific pattern due to the effects of systemic androgens and genetic factors (Salman et al., 2017). In the male pattern phenotype, the hairline at the bi-temporal regions and at the vertex. In the female pattern then is a diffuse thinning with preservation of the frontal hairline. However, the pathogenesis is the same (Levy & Emer, 2013). AGA develops due to a disturbance in the cyclic transformation of hair follicles from active hair shaft growth and pigment production (anagen) to apoptosis-driven (cell death) hair follicle involution (catagen).

Current Treatment

Two medications, topical minoxidil and topical finasteride have shown more promising results (Suchonwanit et al., 2018). Hair transplantation is the only current successful permanent option, and it requires surgical procedures. Several other medical options, such as antiandrogens such as spironolactone, oral contraceptives, cyproterone, flutamide, dutasteride, prostaglandin analogs and ketoconazole are reported to be beneficial (Levy & Emer, 2013). However, they can be associated with significant adverse effects such as depression and elevated liver enzymes. Laser and light therapies have also become popular despite the lack of documented profound benefit.(Levy & Emer, 2013).

Minoxidil was first evaluated for treatment of hair loss in 1984 as a 1% topical solution (Olsen & Weiner, 1987). It became clear that higher concentrations were needed. A 12-month double- blind trial was done on 60 subjects with AGA. The use of twice-daily topical 2% and 3% Minoxidil revealed that at month 4 the average total non-vellus hair counts had increased from a baseline mean of 158.2 to 270.2  (71% increase) in the 2% minoxidil group, from 156.6 to 287.0 (83% increase) in the 3% minoxidil group (Roberts., 1987). At month 12, the means were 415.6 (163% increase) and 448.5 (186% increase) for 2% minoxidil, 3% minoxidil, respectively. The increases from month 4 to month 12 were highly significant for each group (p = 0.0001). More recently, a 5% once-a-day foam has been shown to be equally effective to twice-daily application of lower concentration topical minoxidil (Blume- Peytavi et al., 2011).

Finasteride, a type 2-selective 5?-reductase inhibitor, was approved in 1997 as the first oral pharmacologic therapy for the treatment of men with AGA. It was originally developed for the treatment of men with benign prostatic hyperplasia (BPH) at a dose of 5 mg/day. Subsequent studies demonstrated that finasteride was an effective treatment for men with AGA at an optimal dose of 1 mg/day. The net improvement in hair count (finasteride vs. placebo) was 14% at 1 year and 16% at 2 years (Shapiro & Kaufman, 2003).

A 48-week-long clinical trial of men with AGA was started in November 2018. (https://www.clinicaltrials.gov/ct2/show/NCT0374 2518). The study used an investigational new topical drug called SM04554. Phase III trials were completed in January 2021; however, no results are published at this time. It has shown some promising results in early Phase I and II trials and works by modulating the Wnt pathway that is postulated to initiate and maintain the anagen phase of the hair cycle. Wnt signaling also causes dermal progenitor cells to differentiate into new hair follicles. It is interesting to note that CBD has also been shown to increase Wnt signaling (Vallée et al., 2017). However, to date there is little basic science or clinical research on CBD and Wnt signaling.

Recently, with the increasing acceptance of cannabis sativa-based therapies, cannabidiol (CBD) has come under consideration as a possible, effective, safe, inexpensive non-prescription, topical AGA therapy (Expert Committee on Drug Dependence, 2018). CBD works through the endocannabinoid system (ECS) in the body and has novel effects on hair follicle elongation and hair matrix keratinocytes activated through ECS receptors in the hair follicle cells (Bíró et al., 2009). As such, the therapeutic effects of CBD would complement the physiologic effects of minoxidil, finasteride and antiandrogen therapies.

ECS and Hair Follicles

The ECS was only discovered in the 1990s. In essence, it is a system involved with maintaining cellular homoeostasis in response to excess oxidative stress. It down-regulates the damaging inflammatory response, and up-regulates regenerative processes. It is comprised of two receptors, cannabinoid receptor 1 and 2 (CB1 and CB2) and has two messenger molecules known as the endocannabinoids, anandamide (AEA) and 2- arachidonylglycerol (2-AG). One of the many systems that the ECS is involved with is thermoregulation within the skin. There are a substantial number of CB1 and CB2 receptors on various cell lines within the skin (Tóth et al., 2019). CB1 receptors are well expressed in the hair follicle cells. Stimulation of the CB1 receptor with the endocannabinoids leads to  decreased hair shaft elongation (Telek et al., 2007).

Studies have shown that the ECS is a key player in hair follicle cell growth control. (Bíró et al., 2006; Telek et al., 2007; Tóth et al., 2019). The hair follicle cycle (anagen, catagen, telogen phases) is controlled by the vanilloid receptor-1 (TRPV1; Bíró et al., 2006).TRPV1 receptors are found on the hair matrix keratinocytes. Mouse studies have shown that activation promotes hair follicle regression (catagen) and hair matrix keratinocyte apoptosis (cell death) thru retarding hair shaft elongation. (Bíró et al., 2006). Endocannabinoids, and cannabis-derived phytocannabinoids, such as THC and CBD message TRPV1 receptors. It is postulated that CBD has therapeutic effects via TRPV1 receptors by excessive activation of the receptor that they become desensitized. (Muller et al., 2019).

Tetrahydrocannabinol (THC) is a CB1 receptor partial agonist, and it has been shown to dose-dependently inhibit hair shaft elongation, decrease proliferation of hair matrix keratinocytes and induce intraepithelial apoptosis and premature hair follicle regression (catagen). These effects which occur with our innate endocannabinoid anandamide and with plant-based THC were inhibited by a selective CB1 antagonist. Furthermore, the studies revealed that CB1 receptors were expressed in a hair cycle-dependent manner on the hair follicle. (Bíró et al., 2006; Telek et al., 2007).

The available research suggests that THC and other CB1 agonists can be used to manage unwanted hair growth, and likewise, CB1 antagonists, such as CBD and tetrahydrocannabivarin (THCV) and cannabidivarin (CBDV) can be used to promote hair growth (Telek et al., 2007). CBD is a CB1 antagonist that likely has its effects via negative allosteric modulation of the CB1 receptor (Chung et al., 2019; Laprairie et al., 2015). THCV and CBDV have more potent direct antagonistic effects on the CB1 Receptor. A more recent study of human hair follicle cultured cells (Szabó et al., 2017) revealed that use of lower doses of CBD resulted in hair shaft elongation, likely via CB1 antagonism. However, much higher doses resulted in premature entry into the catagen phase, probably via a different receptor, the vanilloid receptor-4 (TRPV4). Therefore, the dosing of the topical CBD needs to be evaluated in order to obtain positive hair regrowth.

CBD

Over the past decade CBD has been extensively researched for a myriad of therapeutic benefits (Expert Committee on Drug Dependence, 2018). CBD does not cause euphoria or addiction.

It has a wide therapeutic window and few adverse  effects. Topical application of CBD has not been associated with any significant adverse effects (Bíró et al., 2009; Tóth et al., 2019). CBD in an oral  form has been FDA approved for treatment of recalcitrant epilepsy and is now an over-the- counter drug (www.Epidoloex.com). CBD in sublingual, oral, inhaled and topical versions are relatively inexpensive and widely available as nutraceuticals. It is estimated that as many  as 14% of the United States population has tried CBD products. (Corroon & Phillips, 2018).

CBD is fat-soluble and poorly absorbed past the epidermis, but topical application of CBD easily reaches hair follicles where it is a CB1 antagonist, and TRPV1, and TRPV4 agonist (Szabó et al., 2017).

The Present Study

The study was conducted to evaluate the efficacy of daily topical application of a CBD-rich hemp oil formation on AGA. Secondary goals of the study were to look for adverse effects associated with the daily topical application. Based on the pre-clinical evidence of the hair regrowth benefits of antagonizing the CB1 receptors, and from over stimulating TRPV1 receptors we would expect a significant increase in hair follicles in the treated areas.

METHODS

The study is a case series of adults presenting to a ‘Hair and Scalp’ center in Clearwater Florida. Adult subjects, not currently using minoxidil or finasteride were offered the opportunity to receive the hemp oil extract free of charge through Facebook advertising. The first thirty-five subjects who responded were selected (28 males, 7 females). All were Caucasian and were diagnosed with AGA based on the presence of gradually progressing bitemporal and/or vertex alopecia. Clinical diagnosis of AGA with Norwood- Hamilton Classification score of 3V or 4.

The Norwood-Hamilton Classification is used to score stages of male pattern baldness, from 1-7. Stage 3V vertex: There is slight recession of the hairline around the temples, but there is significant hair loss on the top of the scalp (the vertex). Stage 4: The hairline recession is more than slight recession of the hairline around the temples, and there is sparse hair or no hair on the vertex. The two areas of hair loss are separated by a band of hair that connects to the hair remaining on the sides of the scalp.

The predefined endpoints were hair counts obtained in a defined, representative area of scalp hair loss, and investigator clinical assessment of hair growth. The females were ages 46-76 (average age 61) and the males 28-72 (average age 43). The subjects gave their written informed consent for this six-month trial. The study adhered to the Helsinki guidelines and was institutionally approved. Each participant was provided with an informed consent form that they signed. None of the subjects were currently using minoxidil or finasteride. No other hair loss treatments were used during the six months of the research.

The subjects were given a topical extract in a 2 oz jar once a month and advised to apply a thin layer once each morning to the areas of baldness. The subjects were advised that they could use blow dryers, conditioners and other hair preparations. The 2 oz topical was replaced as needed at monthly visits at throughout the six-month trial. The amount used varied significantly based on the area of the scalp to be treated. None of the subjects used more than 2 oz in any one-month period.

The topical extract was made of high CBD cannabis sativa (hemp) flower that had been ultra-pulverized into a fine powder. This chalk-like green powder was independently analyzed by Cannalysis Labs in Santa Ana, CA. It was found to contain 10.78% CBD, and 0.21% THC, and there was no detectable THCV or CBDV. This powder was infused into a lanolin base paste and natural Emu oil carrier. Each 2 oz jar contained 1000 mg of the power, or 108 mg of CBD. The subjects were advised to apply thin layer of the paste over all bald or balding areas once each morning. The 2 oz jar lasted approximately one month, which is an average daily dose of 3-4mg of topically applied CBD.

A hair count of the greatest area of alopecia was carried out before treatment was started and again after six months of treatment. To facilitate consistent hair count analysis, a clear acrylic mold was made of each subject’s head. The front of the mold was positioned at the hair line, with additional measurements from the tip of the nose to the front of the mold. A one-centimeter square was removed from the mold in the area of greatest alopecia, which was either in the temporal or vertex region. The hair count was done within the 1 cm area. The nonvellus hairs within the one square centimeter were pulled through the opening with a surgical skin hook. A Bodelin ProScope with fifty times magnification was used to perform hair counts.

RESULTS

The specific data and hair count for each subject is demonstrated in Table 1.

Temporal Area. This table reveals that hair counts in the temporal area increased an average of 74.1% in men, and 55.2% in women. In men the number of hairs increased from baseline of 20.6 to 33.7 (paired t-test p< 0.01) in the temporal area, and in women from 20.3 to 30.5 (paired t-test p< 0.01)

Vertex Area. In the vertex area the hair counts increased an average of 120.1% for men, and 64.9% for women. In men, the number of hairs increased from baseline of 16.8 to 32.9 (paired t- test p < 0.01) in the temporal area, and in women from 18.7 to 30.7 (paired t-test p < 0.01).

For all males, the baseline hair count was 18.28 (95% Confidence Interval +/- 3.02) and at six months it was 33.21 (95% Confidence Interval +/- 4.86). For all females, the baseline hair count was 19.57 (95% Confidence Interval +/- 4.83) and at six months it was 30.57 (95% Confidence Interval +/- 7.51). The paired samples t-value for men before and after difference was 7.38 (p <0.00001). The paired samples t-value for women before and after difference was 5.56 (p =0.0014).

The hair count increased 93.5%, from 18.5 to 32.7 (p < 0.001) when temporal and vertex areas were combined. In general males and the vertex area did the best. All subjects had some increase in hair count. No self-reported survey of cosmetic appearance was done.

One-third of the patients reported some slightly increased hair shedding during the first month of treatment, this was no longer was noted at the two-month visit. Otherwise, there was no reported adverse effects from use of the extract.

DISCUSSION

This case study supports significant hair regrowth benefits in both men and women with AGA. In general, men did slightly better than women, and the vertex area did better than the temporal areas. On average, there was 93.5% increase in non-vellus hair after six months of once-daily use. All subjects had some regrowth.

The exact mechanism of therapeutic effects is not entirely clear, and furthermore, definitive research is planned. CBD may be functioning as a CB1 receptor antagonist via negative allosteric effects, excessive TRPV1 agonism and potentially also via Wnt messaging. The dosing of the CBD needs to be further evaluated as preclinical research suggests that much higher doses of CBD may cause agonistic effects at TRPV4 receptors which can cause premature entry of the hair follicle into the catagen phase, thereby inhibiting hair growth. (Boudaka et al., 2020).

The safety of topically applied CBD has been previously well-documented (Bíró et al., 2009; Expert Committee on Drug Dependence, 2018). Once again, there is no reported significant adverse effects for six-month application of this CBD topical.

Since the CBD works through novel mechanisms entirely different from both finasteride and minoxidil, it can be used in conjunction with these current drugs and could be expected to have synergistic effects just as finasteride and minoxidil have been shown to have synergism (Suchonwanit et al., 2018).

Further research is planned with a hemp extract that is high in CBD, THCV and CBDV. In addition, comparative, cross-over studies with minoxidil should be considered.

REFERENCES

Bíró, T., Bodó, E., Telek, A., Géczy, T., Tychsen, B., Kovács, L., & Paus, R. (2006). Hair cycle control by vanilloid receptor-1 (TRPV1): evidence from TRPV1 knockout mice. The Journal of Investigative Dermatology, 126(8), 1909-1912.

Bíró, T., Tóth, B. I., Haskó, G., Paus, R., & Pacher, P. (2009). The endocannabinoid system of the skin in health and disease: novel perspectives

and therapeutic opportunities. Trends in Pharmacological Sciences, 30(8), 411-420.

Blume-Peytavi, U., Hillmann, K., Dietz, E., Canfield, D., & Bartels, N. G. (2011). A randomized, single-blind trial of 5% minoxidil foam once daily versus 2% minoxidil solution twice daily in the treatment of androgenetic alopecia in women. Journal of the American Academy of Dermatology, 65(6), 1126-1134.

Boudaka, A., Al-Yazeedi, M., & Al-Lawati, I. (2020). Role of Transient Receptor Potential Vanilloid 4 Channel in Skin Physiology and Pathology. Sultan Qaboos University Medical Journal, 20(2), e138.

Chung, H., Fierro, A., & Pessoa-Mahana, C. D. (2019). Cannabidiol binding and negative allosteric modulation at the cannabinoid type 1 receptor in the presence of delta-9- tetrahydrocannabinol: An In Silico study. PloS one, 14(7), e0220025.

Corroon, J., & Phillips, J. A. (2018). A cross-sectional study of cannabidiol users. Cannabis and Cannabinoid Research, 3(1), 152-161.

Expert Committee on Drug Dependence. (2018). CANNABIDIOL (CBD) Critical review report. World Health Organization. https://www.who.int/medicines/access/controlle d-substances/CannabidiolCriticalReview.pdf

Gupta, A. K., & Charrette, A. (2015). Topical minoxidil: systematic review and meta- analysis of its efficacy in androgenetic alopecia. Skinmed, 13(3), 185-189.

Laprairie, R. B., Bagher, A. M., Kelly, M. E. M., & Denovan-Wright, E. M. (2015). Cannabidiol is a negative allosteric modulator of the cannabinoid CB1 receptor. British Journal of Pharmacology, 172(20), 4790-4805.

Levy, L. L., & Emer, J. J. (2013). Female pattern alopecia: current perspectives. International Journal of Women’s Health, 5, 541.

Muller, C., Morales, P., & Reggio, P. H. (2019). Cannabinoid ligands targeting TRP channels. Frontiers in molecular neuroscience, 11, 487.59

Olsen, E. A., & Weiner, M. S. (1987). Topical minoxidil in male pattern baldness: effects of discontinuation of treatment. Journal of the American Academy of Dermatology, 17(1), 97-101.

Roberts, J. L. (1987). Androgenetic alopecia: treatment results with topical minoxidil. Journal of the American Academy of Dermatology, 16(3),705-710.

Salman, K. E., Altunay, I. K., Kucukunal, N. A., & Cerman, A. A. (2017). Frequency, severity and related factors of androgenetic alopecia in dermatology outpatient clinic: hospital-based cross-sectional study in Turkey. Anais Vrasileiros de Dermatologia, 92(1), 35-40.

Shankar, D. K., Chakravarthi, M., & Shilpakar, R. (2009). Male androgenetic alopecia: population-based study in 1,005 subjects. International Journal of Trichology, 1(2), 131.

Shapiro, J., & Kaufman, K. D. (2003, June). Use of finasteride in the treatment of men with androgenetic alopecia (male pattern hair loss). In Journal of Investigative Dermatology Symposium Proceedings (Vol. 8, No. 1, pp. 20-23). Elsevier.

Suchonwanit, P., Srisuwanwattana, P., Chalermroj, N., & Khunkhet, S. (2018). A randomized, double-blind controlled study of the efficacy and safety of topical solution of 0.25% finasteride admixed with 3% minoxidil vs. 3% minoxidil solution in the treatment of male androgenetic alopecia. Journal of the European Academy of Dermatology and Venereology, 32(12), 2257-2263.

Szabó, I. L., Herczeg-Lisztes, E., Szollosi, A. G., Szegedi, A., Bíró, T., & Oláh, A. (2017). 263 (-)- cannabidiol differentially influences hair growth. Journal of Investigative Dermatology, 137(10), S238.

Telek, A., Bíró, T., Bodó, E., Tóth, B. I., Borbíró, I., Kunos, G., & Paus, R. (2007). Inhibition of human hair follicle growth by endo-and exocannabinoids. The FASEB Journal, 21(13), 3534-3541.

Tóth, K. F., Ádám, D., Bíró, T., & Oláh, A. (2019). Cannabinoid Signaling in the Skin: Therapeutic Potential of the “C (ut) annabinoid” System. Molecules, 24(5), 918.

Vallée, A., Lecarpentier, Y., Guillevin, R., & Vallée, J. N. (2017). Effects of cannabidiol interactions with Wnt/?-catenin pathway and PPAR? on oxidative stress and neuroinflammation in Alzheimer’s disease. Acta Biochimica et Biophysica Sinica, 49(10), 853-866.

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Corresponding Author: Gregory L. Smith, MD, MPH, Medical Life Care Planners, St. Pete Beach, FL, e-mail: MedicalMarijuana@Mail.com

Funding and Acknowledgements: There were no sources of funding for this study which was conducted by the authors at our own practice. The authors adhered to the US “Federal Policy for the Protection of Human Subjects” (“Common Rule”).

The authors/investigators have no economic interest in, do not act as an officer or a director of any outside entity whose financial interests would reasonably appear to be affected by this research study or its findings. The authors/investigators have no personal, business, or volunteer affiliations that may give rise to a real or apparent conflict of interest. Relevant Federally and organizationally established regulations and guidelines in financial conflicts are abided by.

Published in Cannabis 2021, Volume 4 (1),

© Author(s) 2021 researchmj.org. DOI: 10.26828/cannabis/2021.01.003

 

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Cannabis Increases Hair Growth

A recent report “Hair Regrowth with Cannabidiol (CBD) – Rich Hemp Extract” published in peer reviewed journal, “Cannabis”, indicates that CBD contributes to increased hair growth. The following is a brief extract.

Androgenetic alopecia (AGA) is the most common cause of hair loss. Several FDA approved medications are available but offer limited results. Studies have shown that the endocannabinoid system (ECS) is a key player in hair follicle cell growth.

A study was done of 35 subjects with AGA using a once daily topical hemp oil formulation, averaging about 3-4 mg per day of CBD and minimal amounts of other cannabinoids for six months. A hair count of the greatest area of alopecia was carried out before treatment and again after six months.

The results revealed that men did slightly better than women, and the vertex area did better than the temporal areas.
On average, there was statistically significant 93.5% increase in hair after 6 months.
All subjects had some regrowth.

There were no reported adverse effects. Since the CBD works through novel mechanisms different from finasteride and minoxidil, it can be used in conjunction with these current drugs and would be expected to have synergistic effects.

Androgenetic Alopecia (AGA) is a very common condition, that occurs in both men and women, and increases in prevalence with age. It is by far the most common cause of baldness and hair thinning. It generally starts in the third and fourth decades of life and significantly increases in prevalence in women after menopause. It is estimated that 50% of Caucasian men and 19% of Caucasian women are affected by age 50 (Shankar et al., 2009). There is a lower prevalence and severity of the condition in Asian and black men.

AGA may adversely impact a person both psychologically and socially, especially in women (Levy & Emer, 2013). The condition is characterized by follicular miniaturization in a specific pattern due to the effects of systemic androgens and genetic factors (Salman et al., 2017). In the male pattern phenotype, the hairline at the bi-temporal regions and at the vertex. In the female pattern then is a diffuse thinning with preservation of the frontal hairline. However, the pathogenesis is the same (Levy & Emer, 2013). AGA develops due to a disturbance in the cyclic transformation of hair follicles from active hair shaft growth and pigment production (anagen) to apoptosis-driven (cell death) hair follicle involution (catagen).

“Cannabis” is an open access peer-reviewed journal dedicated to the scientific study of marijuana/cannabis from a multidisciplinary perspective. Consistent with the mission of the Research Society on Marijuana (RSMj), the journal publishes empirical research of the determinants, correlates, consequences, contexts, and assessment of marijuana use.

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More About Stem Cells

While other markets reel from the Covid-19 pandemic, the personal care and beauty markets continue their solid growth, with premium brands leading the way. The global beauty market expanded by a full 6% in 2018, reaching $320 billion in retail sales.

Source: Euromonitor and J.P. Morgan estimates

Technology is playing a major part in this growth with medical research, artificial intelligence  and social media playing a key role. Consumers are also looking for more personalized therapies and solutions. A good example is NeoGenesis.

NeoGenesis is a US company in the business of providing skin care and hair care products that enhance people’s quality of life by returning their skin and hair to glowing health. Their products help the skin rebalance and heal itself naturally through  patented stem cell technology.  Their science enables them to harvest an array of molecules from multiple stem cell types. These molecules are the same molecules the skin produces in greater abundance when it is young and healthy, and when applied to aged, damaged skin return the skin to a healthier, more youthful state.

These molecules are packaged in, and protected by, exosomes. Exosomes are naturally produced by the stem cell to carry these molecules to the areas of the skin that need them most. Exosomes house their own intelligence and are superior to liposomes for several reasons that are explained in this video.

The combination of the molecules and the exosome delivery system make Neogenesis products some of the most natural products on the market. These molecules are complimented by a host of other ingredients that your skin needs to nourish itself for rebalanced skin, scientifically known as “Homeostasis Restoration”.

To learn more about the research and science behind the Neogensis hair and skin care products, Hair Authority reached out to Greg Maguire, Ph.D., Neogenesis Founder & Chief Scientific Officer

Dr. Maguire, with more than 30 years of stem cell research, was a part of the science teams that ultimately created a number of the earlier generation stem cell products in the skin care market. This latest technology has benefited tens of thousands of people around the world.  Dr. McGuire recorded a brief video for Hair Authority readers which we have made available on YouTube.

Dr. Maguire pursued his graduate training at the University of California, Berkeley, University of Houston, University of Texas, The Marine Biological Labs, Woods Hole, MA, and Cold Spring Harbor Laboratory, NY. He is a former professor of neuroscience and ophthalmology at the University of California, San Diego School of Medicine, a visiting associate professor of physiology at Keio University School of Medicine in Tokyo, Japan, visiting assistant professor of molecular neurobiology at the University of Washington, and a visiting scientist at Massachusetts General Hospital (MGH), at Harvard University.

Awarded a prestigious Fulbright-Fogarty Fellowship from the National Institutes of Health, Dr. Maguire managed his NIH funded laboratory at UCSD studying tissue degeneration and regeneration, and the role of stem cell released molecules (SRM) through paracrine and autocrine actions to maintain, repair, and regenerate human tissues. His NIH funded studies of systems biology and reverse engineering at the University of California, Berkeley and stem cell biology at UC San Diego led to the development of adult stem cell-based S²RM® technology for the development of therapeutics and medical procedures.

Dr. Maguire has over 100 publications and is currently working on his book entitled, “Spontaneous Stem Cell Healing”.